LEAN MUSCLE GROWTH
ANDARINE S4 is a SARM (selective androgen receptor modulator). But the idea for s4 didn’t start out as many belief. It wasn’t an attempt to create a safer version of steroids or any of that nonsense people use to sell anabolics. Andarine s4 increase the production of muscle mass and calcium for bone density but was completely selective in its tissue growth.
HOW ANDARINE S4 WORKS
There are 3 types of chemicals that act on the androgen receptor (AR):
- 1st is the AR ANTAGONIST, which is a chemical that binds to the receptor to prevent it from activating.
- 2nd is an AR AGONIST, which binds to the receptor and detaches, then binds again, over and over.
- 3rd is an AR MODULATOR, or basically a molecule that attacks to an AR and changes its structure to react however it wants.
A SARM such as s4 is a good example. S4 forces it to produce genes that exclusively benefit muscle and bone growth. In other words, S4 is a form of SARM that attaches to the androgen receptor (AR) the same with regular androgens, the only variation is that s4 generates selective anabolic activity.
As mentioned earlier, SARMS function by tying to the AR resulting in anabolic activity. Due to this fastening and stimulation, more protein is produced which allows muscle building. S4 can trigger muscle development in the same way as steroids, but minus the same unwanted side effects.
S4 is a SARM with utmost androgenic effects and is 33% of the strength of testosterone when attaching to AR.
S4 also increase the amount of muscle mass produced by desensitizing the AR to the individual’s natural testosterone to influence a stronger effect.
THE KEY BENEFITS OF S4
S4 is by far the most versatile SARM ever created. Not only is it the first SARM approved for a stage 2 research study, but it has also become the most analyzed and investigated SARM so far. After the discovery of its anabolic potential, the primary purpose of S4 aimed to develop an alternative treatment to age-related muscle wasting, osteoporosis, and similar symptoms of hypogonadism or end-stage renal disease.
Aside from preserving lean body mass, S4 can also help improve it.
From a stage 1 study, S4 has provided evidence of a 3.3lbs increase in less than 90 days with no increase or change in daily diet. An unintended side effect (or benefit if you will) is the decrease in body fat. Decreases in body fat are dependent on the person’s genetics, but it will definitely have strong effects on the body’s ability to oxidize fatty tissue. S4 was found to not only have a great affinity (potency in binding to androgen receptors), while also presenting greater anabolic effects than some traditional steroids.
Aside from its muscle building advantages, S4 won’t cause liver damage, can prevent gynecomastia (enlarged breasts in men) and can help boost your overall health.
Some of the advantages of S4-
- Very minimal growth on secondary sexual organs such as the prostate.
- The LDL/HDL ratio is not affected which makes it a low cardiovascular risk.
- 0% chance of aromatization, male breast lactation, or rise in any other female characteristic during the post cycle recovery.
- Testosterone is not diminished in any capacity during the post cycle recovery.
- very exclusive in tissue selection and growth which means it will not cause heart enlargement or damage to neighbouring organs.
- SARMS do not require the utilization or devouring of liver enzymes to activate their anabolic effects. This eliminates any risk of hepatotoxicity or hepatitis.
- Although SARMS such as S4 is not as powerful as comparable steroids such as Winstrol, they do not require the extensive post cycle therapy and can be cycled back to back throughout the year. Over the course of a year, obtaining the same results is very possible.
- SARMS is very female friendly and does not cause excessive masculine features such as enlarged sexual characteristics.
- S4 has overall presented larger increases in muscle mass than DHT.
THE SIDE EFFECTS
Unfortunately, there are always some side effects that arise when using because S4 is a ligand by definition, the side effects will never be permanent even at supraphysiological dosages and can be easily avoided through proper dosing. Also, Andarine follows the law of diminishing returns meaning that over time, your body will develop a tolerance and the SARM will become less effective after a certain milligram percentage. For the average person, it ranges from 50mg to 75mg, there are people that can go above this range for even more amazing results or need to say below this range because they are unable to tolerate the chemical. About 99.5% of the population should fall within the 50mg to a 75mg range.
The most popular negative effects of S4 are visual issues such as the yellow tint and difficulty adjusting to night vision. These side effects are unique to S4 and are sometimes overblown. If these side effects present themselves, simply stop taking S4 for two days and stay at a 5 day on/ 2 day 0ff. These effects are not permanent! Once a ligand (such a SARM) leaves the system, its effects disappear completely.
Lastly, S4 and most other SARMS have been known to cause depression in a small population of people. This has been discovered as more of a psychological issue than a physiological issue, researches with mice suffering from any emotional disorders need to be cautious when using this chemical.
ANDARINE DOSING GUIDELINES
Benefits of Andarine have been reported with dosages ranging between 25mg and 50mg 3x per day.
Unfortunately, the higher the dosage, the higher the side effects. S4 is a rare form SARM that has a greater risk of side effects than most other SARMS.
These effects are not permanent. S4 has been proven safe and effective for cycles up to 3 months.
One study in particular compared S4 to DHT ( a common anabolic steroid) the results have shown that S4 exceeded DHT in producing lean muscle mass over the course of 120 days with the only 3mg per day. Another study identified that S4 is completely absorbed even at very low doses.
Here are some more general guidelines depending on goals.
- Most people have opted to split their 50mg to 75mg doses into 3 separate doses (one with each meal), 5 days per week for no more than 12 t 16 weeks. This has become somewhat of a dogma but there are no studies proving that it is any more effective than one solid dose once a day.
- S4 does have a point of diminishing returns. This means usage of S4 passed 75mg or usage of S4 for more than 16 weeks will not result in any added muscle mass. There will not be an increase in side effects either, but you will be running the risk of AR desensitization and inevitably wasting your product.
- Dosing with for less than 6-8 weeks is not recommended and will not allow the researcher to witness the full benefits of the product.
The recommended dose for cutting is 50mg for 6-8 weeks. You should use it every day then take 2 days off for the duration. Taking S4 daily for the length of the cycle can lead to changes in eyesight.
USES OF ANDARINE
Andarine properties are very alike with steroids ANAVAR and WINSTROL, the only difference is that S4 can better provide lean muscle gains. In fact, there have been many cases of bodybuilders gaining up to 3 pounds of lean muscle while o a caloric deficit. S4 displays the same binding resemblance to AR, hence presenting similar fat-burning effects. S4 can also minimize LPL (lipoprotein lipase) an enzyme that causes lipid accumulation and plays a role in storing adipose tissue (excess body fat). The AR oxidizes this adipose tissue and uses it as its preferred energy source, allowing the body to decrease excess fat at an amazing rate.
It also improves vascularity for that aesthetic chiselled look with minimal to no water retention. Unlike steroids, it won’t affect your joints but reinforce muscle mass and power instead. You can also say goodbye to painful pumps.
RECOMMENDED DOSAGE: 50mg for 8-12 WEEKS.
Take 2 days off when taking S4 ( repeat the cycle after a 2-day break) to avoid side effects.
Use S4 with a more anabolic SARM such as Ostarine for better recomp results as you’re aiming to gain muscle while losing fat.
RECOMMENDED DOSAGE: 50-75mg for 8-12 WEEKS
S4 isn’t the sarm that comes to mind when we think BULKING but it’s properties in muscle gain shouldn’t be overlooked. During the holiday season, many people take advantage of the excess food and snacks available and jump on some well known bulking SARMS such as LGD 4033 or RAD 140. While there isn’t an enormous 15lb leap in the muscle like these bulk specific products, S4 can provide relatively large muscle gains and utilize these excess calories to provide an extra 8-10 lbs in muscle while also keeping the body relatively lean. This steady increase in muscle mass can limit the amount of work one needs to do for a leaner summer body.